Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-fluorobenzoate → Methyl cis(+/-)-3-(4-amino-3-methoxypiperidin-1-yl)-5-fluorobenzoate
반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[C:26]([F:28])[CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[C:26]([F:28])[CH:27]=2)[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30]참가 물질
3
실험 절차
The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-5-fluorobenzoate obtained in Example (175a) (78 mg, 0.19 mmol) and a 10% palladium-carbon catalyst (100 mg), to obtain the title compound as a yellow oily substance. The resulting compound was used for the next reaction without purification.
출처 및 근거
- ORD 기록
- ord-d0cf93f20f7543deaf6b3843c914cb54
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08927588B2
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