Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate → HCID 86648746, 화합물

HRID 1425263

반응식

HRID 1425263 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=2[F:28])[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=2[F:28])[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30]

참가 물질

3

반응물 1

HCID 86648744Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate

생성물 1

HCID 86648746HCID 86648746, 화합물수율 26.6%

시약·촉매·용매 1

HCID 178418390HCID 178418390, 화합물촉매

실험 절차

The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate obtained in Example (181a) (101 mg, 0.24 mmol) and a 10% palladium-carbon catalyst (100 mg), to obtain 18 mg of the title compound as a colorless oily substance (26%). The resulting compound was used for the next reaction without purification.

출처 및 근거

ORD 기록
ord-2b1d63cc4f354e2ab8c2aa25595ec4ce
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08927588B2

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