7-Bromo-1-Chloroisoquinoline → 7-Bromoisoquinoline

HRID 14253

반응식

HRID 14253 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][CH:3]=1>C(O)(=O)C.[Zn]>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 65020247-Bromo-1-Chloroisoquinoline

생성물 1

HCID 122574417-Bromoisoquinoline수율 86.8%

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

A solution of 7-bromo-1-chloroisoquinoline (2.50 g, 10.3 mmol) and activated zinc (1.40 g, 21.65 mmol) in acetic acid (20 mL) was heated at reflux for 2 h. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting residue was partitioned between ethyl acetate and water. The organic layer was washed with saturated sodium chloride, dried (sodium sulfate), filtered, and concentrated under reduced pressure to provide 7-bromoisoquinoline (1.86 g): ESI MS m/z 208 [M+H]+.

후처리

  1. temperatureat reflux for 2 h
  2. concentrationconcentrated under reduced pressure
  3. customThe resulting residue was partitioned between ethyl acetate and water
  4. washThe organic layer was washed with saturated sodium chloride
  5. dry with materialdried (sodium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-51725a07dc75426cb2d226d4e7ea7d78
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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