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tert-Butyl cis(+/-)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate → tert-Butyl cis(+/-)-4-amino-3-(dimethylamino)piperidine-1-carboxylate

HRID 1425309
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HRID 1425309 반응식
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:14][C@H:13]1[N:25]([CH3:27])[CH3:26])=O)C1C=CC=CC=1.[H][H]>CO.[OH-].[Pd+2].[OH-]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:19])[CH2:14][C@H:13]1[N:25]([CH3:27])[CH3:26]
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참가 물질

5

반응물 2

HCID 86648775tert-Butyl cis(+/-)-4-{[(benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 86648776tert-Butyl cis(+/-)-4-amino-3-(dimethylamino)piperidine-1-carboxylate수율 100.3%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

20% Palladium hydroxide (15 mg) was added to a solution of tert-butyl cis(±)-4-{[benzyloxy)carbonyl]amino}-3-(dimethylamino)piperidine-1-carboxylate obtained in Example (200b) (144 mg, 0.381 mmol) in methanol (4 mL) at room temperature, and the mixture was stirred in a hydrogen atmosphere at 50° C. for six hours. The insoluble matter was separated by filtration, and the filtrate was concentrated under reduced pressure to obtain 93 mg of the title compound (100%) as a colorless oily substance.

후처리

  1. customThe insoluble matter was separated by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7b281f9757a54fbab899ae1f450baae7
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08927588B2

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