Ethanol → 2,2-dimethyl-5-(thiazol-4-yl)furan-3(2H)-one

반응식

O[C:2]([CH3:13])([CH3:12])[C:3]#[C:4][C:5]([C:7]1[N:8]=[CH:9][S:10][CH:11]=1)=[O:6].C(NCC)C.C([OH:21])C>>[CH3:12][C:2]1([CH3:13])[C:3](=[O:21])[CH:4]=[C:5]([C:7]2[N:8]=[CH:9][S:10][CH:11]=2)[O:6]1

참가 물질

반응물 3

HCID 702Ethanol2회

HCID 8021Diethylamine

HCID 59354863HCID 59354863, 화합물

생성물 1

HCID 593548052,2-dimethyl-5-(thiazol-4-yl)furan-3(2H)-one

실험 절차

To a stirred solution of 4-hydroxy-4-methyl-1-(thiazol-4-yl) pent-2-yn-1-one (0.1 g, 0.53 mmol) in ethanol (1 mL) was added diethyl amine (0.057 mL, 0.59 mmol) in EtOH (0.5 mL) dropwise at RT and the reaction mixture was stirred for additional 45 min. Then the EtOH was removed, diluted with EtOAc (10 mL), washed with water (5 mL), brine (5 mL), dried over Na2SO4, filtered and concentrated in vacuo to afford 2,2-dimethyl-5-(thiazol-4-yl) furan-3(2H)-one (0.1 g) as an oil.