반응식
[CH3:1][C:2]1[N:3]=[C:4]([NH:7][C:8]2[C:13]([OH:14])=[CH:12][CH:11]=[CH:10][N:9]=2)[S:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].[Cl:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([O:29][CH3:30])[CH:24]=1>>[ClH:21].[CH3:30][O:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[CH2:22][O:14][C:13]1[C:8]([NH:7][C:4]2[S:5][CH:6]=[C:2]([CH3:1])[N:3]=2)=[N:9][CH:10]=[CH:11][CH:12]=1참가 물질
4
실험 절차
2-(4-Methylthiazol-2-ylamino)pyridin-3-ol (prepared according to Example 3, Step A) (0.150 g, 0.724 mmol), K2CO3 (0.225 g, 1.63 mmol), and 1-(chloromethyl)-3-methoxybenzene (0.113 g, 0.724 mmol) were reacted according to Example 3, Step B, to provide 3-(3-methoxybenzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine hydrochloride (0.110 g, 46.4% yield). 1H NMR (CDCl3) δ 12.34 (bs, 1H), 7.93 (dd, 1H), 7.28 (d, 1H), 7.20 (m, 1H), 7.12 (m, 2H), 6.97 (m, 1H), 6.84 (m, 1H), 6.38 (s, 1H), 5.34 (s, 2H), 3.84 (s, 3H), 2.47 (s, 3H). Mass spectrum (apci) m/z=328.1 (M+H-HCl). Analysis calculated for C17H18N3O2ClS.0.54DCM: C, 56.29; H, 5.14; N, 11.23. found: C, 56.29; H, 5.23; N, 11.01.
출처 및 근거
- ORD 기록
- ord-7c9e01c5095d4299becc237e7b9a5f5f
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08933077B2
연결된 노트
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