Acetaldehyde → 1-(5-(Benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)ethanol
반응식
Cl.[CH2:2]([O:9][C:10]1[C:11]([NH:17][C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)=[N:12][CH:13]=[C:14](Br)[CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Li]C.C([Li])CCC.[CH:31](=[O:33])[CH3:32]>>[CH2:2]([O:9][C:10]1[CH:15]=[C:14]([CH:31]([OH:33])[CH3:32])[CH:13]=[N:12][C:11]=1[NH:17][C:18]1[S:19][CH:20]=[C:21]([CH3:23])[N:22]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1참가 물질
5
실험 절차
3-(Benzyloxy)-5-bromo-N-(4-methylthiazol-2-yl)pyridin-2-amine (prepared according to Example 1) (0.350 g, 0.930 mmol), MeLi (0.727 mL, 1.16 mmol), butyllithium (0.465 mL, 1.16 mmol), and acetaldehyde (0.0410 g, 0.930 mmol) were reacted according to the method of Example 7 to provide 1-(5-(benzyloxy)-6-(4-methylthiazol-2-ylamino)pyridin-3-yl)ethanol (0.187 g, 58.8%). Mass spectrum (apci) m/z=342.1 (M+H).
출처 및 근거
- ORD 기록
- ord-47162b9577714390954d1a7960a6dc14
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08933077B2
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