3-Bromo-5-chloropyridine → 2-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

반응식

[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[CH:14])=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=1>>[C:1]([C:5]1[CH:15]=[C:8]2[N:9]=[CH:10][C:11]([C:13]#[C:14][C:17]3[CH:18]=[N:19][CH:20]=[C:21]([Cl:23])[CH:22]=3)=[CH:12][N:7]2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

반응물 2

HCID 6062563-Bromo-5-chloropyridine

HCID 583167022-tert-Butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine

생성물 1

HCID 532473302-tert-Butyl-6-(5-chloro-pyridin-3-ylethynyl)-pyrazolo[1,5-a]pyrimidine

실험 절차

The title compound, light yellow solid, MS: m/e=311.2 (M+H+), can be prepared in accordance with the general method of example 1 from 2-tert-butyl-6-ethynyl-pyrazolo[1,5-a]pyrimidine (example 21, step 2) and 3-bromo-5-chloropyridine.

출처 및 근거

ORD 기록: ord-0a11cc1525174165b8a5a46efe514731
출처 데이터셋: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08933094B2

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