Tetrahydrofuran → HCID 86676230, 화합물

HRID 1426485노트

반응식

HRID 1426485 반응식
[C:1]([O:5][C:6]([N:8]([CH2:17][CH:18]=[CH2:19])[CH:9]([CH2:14][CH:15]=[CH2:16])[C:10](OC)=[O:11])=[O:7])([CH3:4])([CH3:3])[CH3:2].O1CCCC1.[H-].C([Al+]CC(C)C)C(C)C.C1(C)C=CC=CC=1>C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>[OH:11][CH2:10][CH:9]([N:8]([CH2:17][CH:18]=[CH2:19])[C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])[CH2:14][CH:15]=[CH2:16]

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 11108397Methyl 2-[[(1,1-dimethylethoxy)carbonyl]-2-propen-1-ylamino]-4-pentenoateHCID 86583787Diisobutylaluminumhydride toluene

생성물 1

HCID 86676230HCID 86676230, 화합물수율 83.9%

시약·촉매·용매 1

HCID 9855836Potassium sodium tartarate용매

실험 절차

To a mixture of methyl 2-[(tert-butoxycarbonyl)(prop-2-en-1-yl)amino]pent-4-enoate (5.0 g) produced above and tetrahydrofuran (100 mL) was added 1M diisobutylaluminum hydride/toluene solution (60 mL) at 0° C., and the mixture was stirred at the same temperature for 15 min. The reaction mixture was diluted with aqueous potassium sodium tartrate solution, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate. Insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (3.76 g).

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. filtrationInsoluble material was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5958d6c9a3684e60bc90d8ddaed47bd9
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933069B2

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