Methanol → Methyl 1-butylisoquinoline-7-carboxylate

HRID 14268

반응식

HRID 14268 반응식
[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([OH:17])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4].S(=O)(=O)(O)O.[CH3:23]O>>[CH2:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH3:23])=[O:16])[CH:13]=2)[CH:8]=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 210851771-Butylisoquinoline-7-carboxylic acid

생성물 1

HCID 21086138Methyl 1-butylisoquinoline-7-carboxylate

실험 절차

A solution of 1-butylisoquinoline-7-carboxylic acid (325 mg, 1.41 mmol) in methanol (25 mL) containing concentrated sulfuric acid (800 μL) was refluxed overnight. The reaction mixture was then concentrated under reduced pressure, diluted with methylene chloride, washed with water, and saturated sodium chloride. The organic layer was then dried (sodium sulfate), filtered, and concentrated to yield methyl 1-butylisoquinoline-7-carboxylate (350 mg): ESI MS m/z 244 [M+H]+;

후처리

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was then concentrated under reduced pressure
  3. additiondiluted with methylene chloride
  4. washwashed with water, and saturated sodium chloride
  5. dry with materialThe organic layer was then dried (sodium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-7a3169cd7e464668803ed69980273ac8
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07727997B2

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