Isopropanol → HCID 86619830, 화합물

HRID 1426872노트

반응식

HRID 1426872 반응식
[C:1]([O:5][C:6]1[CH:11]=[C:10]([N:12]=[C:13]=[S:14])[CH:9]=[C:8]([F:15])[CH:7]=1)([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH:23]([OH:26])([CH3:25])[CH3:24]>>[CH:23]([O:26][C:13](=[S:14])[NH:12][C:10]1[CH:9]=[C:8]([F:15])[CH:7]=[C:6]([O:5][C:1]([CH3:4])([CH3:2])[CH3:3])[CH:11]=1)([CH3:25])[CH3:24]

참가 물질

4

반응물 3

HCID 3776IsopropanolHCID 8471TriethylamineHCID 86619831HCID 86619831, 화합물

생성물 1

HCID 86619830HCID 86619830, 화합물

반응 조건

온도
0 °C

실험 절차

1-tert-Butoxy-3-fluoro-5-isothiocyanatobenzene (24.0 g) and triethylamine (10.9 g) are dissolved in iso-propanol (150 ml). The reaction mixture is refluxed for 18 hours and the solvent is removed by vacuo. The crude product is dissolved in hexane: diethyl ether (19:1). The diethyl ether is removed in vacuo and the solution is cooled to 0° C. for 3 hours. The solution is filtered to give the title compound.

후처리

  1. temperatureThe reaction mixture is refluxed for 18 hours
  2. customthe solvent is removed by vacuo
  3. dissolutionThe crude product is dissolved in hexane: diethyl ether (19:1)
  4. customThe diethyl ether is removed in vacuo
  5. filtrationThe solution is filtered

출처 및 근거

ORD 기록
ord-e9c21e0a133d41aab1374f00b10ed18f
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933108B2

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