HCID 86705039, 화합물 → 6-Fluoro-1H-indol-4-amine

HRID 1427211노트

반응식

HRID 1427211 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+]([O-])=O)[C:5]([CH:11]=[CH:12][N:13](C)C)=[C:4]([N+:16]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([NH2:16])[C:5]2[CH:11]=[CH:12][NH:13][C:6]=2[CH:7]=1

참가 물질

4

반응물 1

HCID 86705039HCID 86705039, 화합물

생성물 1

HCID 247280226-Fluoro-1H-indol-4-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

2-(4-fluoro-2,6-dinitrophenyl)-N,N-dimethylethenamine (18 g, 0.071 mol) was dissolved in ethanol (1000 mL), and charged with 10% palladium on carbon (2.0 g). The mixture was hydrogenated at room temperature overnight. The mixture was filtrated through celite and washed with ethanol. The filtrate was combined and evaporated in vacuo. The residue was purified by silica gel flash chromatography (PE:EA=2:1) to afford the title compound. LC/MS m/z=151.2 [M+H]+.

후처리

  1. filtrationThe mixture was filtrated through celite
  2. washwashed with ethanol
  3. customevaporated in vacuo
  4. customThe residue was purified by silica gel flash chromatography (PE:EA=2:1)

출처 및 근거

ORD 기록
ord-c4b854530069442caa53645e8a2109f6
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933113B2

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