Hydrochloride methanol → Methyl 3-(4-amino-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

HRID 1427291노트

반응식

HRID 1427291 반응식
C(OC([NH:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)([CH2:27][CH3:28])[CH2:19][C:20]([O:22][C:23](C)(C)C)=[O:21])=O)(C)(C)C.Cl.CO>>[NH2:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH:11]=[CH:12][N:13]2[C:18]([C:29]1[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=1)([CH2:27][CH3:28])[CH2:19][C:20]([O:22][CH3:23])=[O:21]

참가 물질

3

반응물 2

HCID 21893726Hydrochloride methanolHCID 117809455tert-Butyl 3-(4-(tert-butoxycarbonylamino)-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

생성물 1

HCID 68175795Methyl 3-(4-amino-1H-indol-1-yl)-3-(4-chlorophenyl)pentanoate

실험 절차

A mixture of the product of Step F (120 mg, 0.24 mmol) and 4 N HCl/MeOH (2 mL) was stirred at room temperature for 2 h. The volatile was removed in vacuo to give the title compound as colorless oil. LC/MS m/z=357.1[M+H]+.

후처리

  1. customThe volatile was removed in vacuo

출처 및 근거

ORD 기록
ord-c65139464ff94b269e12deba4cee1038
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08933113B2

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