(S)-1-(2,4-Difluorophenyl)ethanamine → HCID 67152322, 화합물

HRID 1428191노트

반응식

HRID 1428191 반응식
Cl[C:2]1[N:7]=[C:6]([S:8][CH3:9])[N:5]=[C:4]([C:10]2[CH:11]=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=23)[CH:3]=1.[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C@@H:27]([NH2:29])[CH3:28]>CN1C(=O)CCC1>[F:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1[C@@H:27]([NH:29][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[N:12][N:13]3[CH:18]=[CH:17][CH:16]=[N:15][C:14]=23)[N:5]=[C:6]([S:8][CH3:9])[N:7]=1)[CH3:28]

참가 물질

4

반응물 2

HCID 2060581(S)-1-(2,4-Difluorophenyl)ethanamineHCID 58268975HCID 58268975, 화합물

생성물 1

HCID 67152322HCID 67152322, 화합물수율 58.6%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

A 7 ml NMP solution of 3-(6-chloro-2-(methylthio)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidine (7h, 1.30 g) and (S)-1-(2,4-difluoro-phenyl)ethanamine (1.47 g) was heated in a microwave reactor at 220° C. for 20 min. LC/MS indicated the major peak was the desired product. The reaction mixture was partitioned between ethyl acetate and sat. NH4OAc. The organic phase was dried with MgSO4, filtered and the solvent was removed under reduced pressure. The product was purified by chromatography (SiO2, EtOAc-Hex, 1:1) (1.09 g, 58.6% yield).

출처 및 근거

ORD 기록
ord-2d55575e489d4b5e846bc867470d3144
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937064B2

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