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Potassium Phosphate, Tribasic → 2-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile

HRID 1428202
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HRID 1428202 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[O-]P([O-])([O-])=O.[K+].[K+].[K+].CC(C1C=C(C(C)C)C(C2C=CC=CC=2P(C2CCCCC2)C2CCCCC2)=C(C(C)C)C=1)C.Br[C:57]1[CH:64]=[CH:63][C:60]([C:61]#[N:62])=[C:59]([F:65])[CH:58]=1>C1(C)C=CC=CC=1>[F:65][C:59]1[CH:58]=[C:57]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=2[C:10]([F:11])([F:12])[F:13])[CH:64]=[CH:63][C:60]=1[C:61]#[N:62]
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참가 물질

6

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HCID 62657Potassium Phosphate, TribasicHCID 7360294-Bromo-2-fluorobenzonitrileHCID 111557942-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 226017214-Methoxy-2-(trifluoromethyl)aniline

생성물 1

HCID 667656782-Fluoro-4-(4-methoxy-2-trifluoromethyl-phenylamino)-benzonitrile수율 87%

시약·촉매·용매 1

HCID 1140Toluene용매

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온도
110 °C

실험 절차

2-Amino-5-methoxy-benzotrifluoride (10.46 mmol), K3PO4 (15.7 mmol), Xphos (1.05 mmol) and Pd4(dba)3 (0.314 mmol) were added under nitrogen to a solution of 4-bromo-2-fluoro-benzonitrile (10.46 mmol) in 50 mL toluene and the mixture was stirred for 20 hours at a bath temperature of 110° C. Then the mixture was filtered through a glass fibre filter, then the filtrate was extracted with 150 mL water. The organic phase was dried on sodium sulphate and evaporated down. In this way the product was obtained in a yield of 87% of theory.

후처리

  1. filtrationThen the mixture was filtered through a glass fibre
  2. filtrationfilter
  3. extractionthe filtrate was extracted with 150 mL water
  4. customThe organic phase was dried on sodium sulphate
  5. customevaporated down
  6. customIn this way the product was obtained in a yield of 87% of theory

출처 및 근거

ORD 기록
ord-16fef055e3bb4594b4fe0f5f07f37451
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08937073B2

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