4-(4-Aminophenoxy)-N-methylpicolinamide → 4-[4-({[4-bromo-3-(pentafluoro-lambda6-sulfanyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide

HRID 1428415노트

반응식

HRID 1428415 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[O:10])=[CH:4][C:3]=1[S:11]([F:16])([F:15])([F:14])([F:13])[F:12].[NH2:17][C:18]1[CH:34]=[CH:33][C:21]([O:22][C:23]2[CH:28]=[CH:27][N:26]=[C:25]([C:29]([NH:31][CH3:32])=[O:30])[CH:24]=2)=[CH:20][CH:19]=1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:17][C:18]2[CH:34]=[CH:33][C:21]([O:22][C:23]3[CH:28]=[CH:27][N:26]=[C:25]([C:29]([NH:31][CH3:32])=[O:30])[CH:24]=3)=[CH:20][CH:19]=2)=[O:10])=[CH:4][C:3]=1[S:11]([F:16])([F:12])([F:13])([F:14])[F:15]

참가 물질

4

반응물 2

HCID 166551294-(4-Aminophenoxy)-N-methylpicolinamideHCID 867012911-Bromo-4-isocyanato-2-(pentafluoro-lambda6-sulfanyl)benzene

생성물 1

HCID 575208864-[4-({[4-bromo-3-(pentafluoro-lambda6-sulfanyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide수율 72%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The crude 1-bromo-4-isocyanato-2-(pentafluoro-λ6-sulfanyl)benzene obtained above was dissolved in DCM (70 mL). 4-(4-aminophenoxy)-N-methylpicolinamide (1.54 g, 6.34 mmol, 0.8 eq) was added at room temperature under N2. The mixture was stirred at room temperature for about 30 min, a lot of solid precipitated. DCM (30 mL) was added and made the mixture stirred at room temperature for 18 hrs. The solid was filtrated, washed with DCM (50 mL), dried under high vacuum to afford 2.6 g (yield 72%) of the title compound as a white solid.

후처리

  1. customa lot of solid precipitated
  2. additionDCM (30 mL) was added
  3. stirringstirred at room temperature for 18 hrs
  4. filtrationThe solid was filtrated
  5. washwashed with DCM (50 mL)
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-e4e5ee69e62a499fa5569d359dd8d324
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937088B2

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