N-(2-fluoro-4-nitrobenzyl)methanesulfonamide → N-(4-amino-2-fluorobenzyl)methanesulfonamide

HRID 1428739노트

반응식

HRID 1428739 반응식
[F:1][C:2]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:3]=1[CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7]>O1CCCC1.C(O)C.[Pd]>[NH2:14][C:12]1[CH:11]=[CH:10][C:3]([CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7])=[C:2]([F:1])[CH:13]=1

참가 물질

5

반응물 1

HCID 86679366N-(2-fluoro-4-nitrobenzyl)methanesulfonamide

생성물 1

HCID 86679367N-(4-amino-2-fluorobenzyl)methanesulfonamide수율 86.5%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of N-(2-fluoro-4-nitrobenzyl)methanesulfonamide (250 mg, 1.007 mmol) in tetrahydrofuran and ethanol as co-solvent were added 10% Pd/C (25 mg). The mixture was charged with H2 (gas) balloon. The resulting mixture was stirred for 15 h, then filtered by using celite. The filtrate was removed in vacuo. The crude was purified by column chromatography. N-(4-Amino-2-fluorobenzyl)methanesulfonamide (190 mg) was obtained as 86% yield.

후처리

  1. additionThe mixture was charged with H2 (gas) balloon
  2. filtrationfiltered
  3. customThe filtrate was removed in vacuo
  4. customThe crude was purified by column chromatography

출처 및 근거

ORD 기록
ord-17862222d0ab44c58a5ceb989df33303
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937092B2

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