Ethyl 2-(3-methoxy-4-nitrophenyl)propanoate → Ethyl 2-(4-amino-3-methoxyphenyl)propanoate
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:6]=[CH:7][C:8]=1[N+:9]([O-])=O>O1CCCC1.C(O)C.[Pd]>[NH2:9][C:8]1[CH:7]=[CH:6][C:5]([CH:12]([CH3:18])[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[CH:4][C:3]=1[O:2][CH3:1]참가 물질
5
실험 절차
To a stirred solution of ethyl 2-(3-methoxy-4-nitrophenyl)propanoate (683 mg, 2.697 mmol) in tetrahydrofuran and ethanol as co-solvent were added 10% Pd/C (70 mg). The mixture was charged with H2 (gas) balloon. The resulting mixture was stirred for 15 h, then filtered using celite. The filtrate removed in vacuo. The crude was purified by column chromatography. Ethyl 2-(4-amino-3-methoxyphenyl)propanoate (447 mg) was obtained as 74% yield.
후처리
- additionThe mixture was charged with H2 (gas) balloon
- filtrationfiltered
- customThe filtrate removed in vacuo
- customThe crude was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-7b4de9b56e794bddb08196e166bc4583
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08937092B2
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