N-(2-methyl-4-nitrobenzyl)methanesulfonamide → N-(4-amino-2-methylbenzyl)methanesulfonamide
반응식
[CH3:1][C:2]1[CH:13]=[C:12]([N+:14]([O-])=O)[CH:11]=[CH:10][C:3]=1[CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7]>O1CCCC1.C(O)C.[Pd]>[NH2:14][C:12]1[CH:11]=[CH:10][C:3]([CH2:4][NH:5][S:6]([CH3:9])(=[O:8])=[O:7])=[C:2]([CH3:1])[CH:13]=1참가 물질
5
실험 절차
To a stirred solution of N-(2-methyl-4-nitrobenzyl)methanesulfonamide (100 mg, 0.409 mmol) in tetrahydrofuran and ethanol as co-solvent were added 10% Pd/C (40 mg). The mixture was charged with H2 (gas) balloon. The resulting mixture was stirred for 24 h, then filtered using celite. The filtrate removed in vacuo. The crude was purified by column chromatography. N-(4-Amino-2-methylbenzyl)methanesulfonamide (61 mg) was obtained as 70% yield.
후처리
- additionThe mixture was charged with H2 (gas) balloon
- filtrationfiltered
- customThe filtrate removed in vacuo
- customThe crude was purified by column chromatography
출처 및 근거
- ORD 기록
- ord-0e2af21424fc4ce3b20a39e69cbb1a37
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08937092B2
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