Ethanesulfonyl chloride → N-(4-bromo-2-fluorobenzyl)ethanesulfonamide
반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[C:4]([F:10])[CH:3]=1.[CH2:11]([S:13](Cl)(=[O:15])=[O:14])[CH3:12]>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][S:13]([CH2:11][CH3:12])(=[O:15])=[O:14])=[C:4]([F:10])[CH:3]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
(4-Bromo-2-fluorophenyl)methanamine (924 mg, 4.53 mmol) was dissolved in pyridine and ethane sulfonyl chloride (0.82 mL, 8.60 mmol) was added to the solution at 0° C. The mixture was stirred for 1 h at 0° C. Then, the mixture was quenched with 1N HCl and extracted with ethyl acetate. Drying over magnesium sulfate and evaporation of the ethyl acetate and purified by column chromatography gave N-(4-bromo-2-fluorobenzyl)-ethanesulfonamide in pure form (1.06 g, 79%).
후처리
- customThen, the mixture was quenched with 1N HCl
- extractionextracted with ethyl acetate
- dry with materialDrying over magnesium sulfate and evaporation of the ethyl acetate
- custompurified by column chromatography
출처 및 근거
- ORD 기록
- ord-4ad33e7a18a64304ac8b533d122f3afb
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08937092B2
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