tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate → tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate

HRID 1428787노트

반응식

HRID 1428787 반응식
[F:1][C:2]1[CH:20]=[C:19]([N+:21]([O-])=O)[CH:18]=[CH:17][C:3]=1[CH2:4][NH:5][S:6]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:8])=[O:7]>C(O)C.O1CCCC1.[Pd]>[NH2:21][C:19]1[CH:18]=[CH:17][C:3]([CH2:4][NH:5][S:6]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])(=[O:8])=[O:7])=[C:2]([F:1])[CH:20]=1

참가 물질

5

반응물 1

HCID 86679394tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate

생성물 1

HCID 86680228tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate수율 102.9%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

10% Pd/C (42 mg) was added to a solution of tert-butyl N-(2-fluoro-4-nitrobenzyl)sulfamoylcarbamate (135 mg) in ethanol and tetrahydrofuran. The mixture was charged with H2 and stirred for 6 h. The reaction mixture was filtered using celite and evaporated in vacuo to obtain tert-butyl N-(4-amino-2-fluorobenzyl)sulfamoylcarbamate (127 mg, 99%).

후처리

  1. additionThe mixture was charged with H2
  2. filtrationThe reaction mixture was filtered
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-f2026a2f811d409e94ebb55f38fa5fbc
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08937092B2

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