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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Isopropylamine → N-cyclopropylsulfonyl-13-methyl-2,14-dioxo-17-[2-(propan-2-ylamino)pyrimidin-4-yl]oxy-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxamide

HRID 1429159
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인쇄 미리보기

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HRID 1429159 반응식
[CH:1]1([S:4]([NH:7][C:8]([C:10]2([NH:15][C:16]([CH:18]3[CH2:22][CH:21]([O:23][C:24]4[CH:29]=[CH:28][N:27]=[C:26](Cl)[N:25]=4)[CH2:20][CH:19]3[C:31]([N:33]([CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=C)[CH3:34])=[O:32])=[O:17])[CH2:12][CH:11]2[CH:13]=C)=[O:9])(=[O:6])=[O:5])[CH2:3][CH2:2]1.[CH:41]([NH2:44])([CH3:43])[CH3:42]>C1COCC1.ClCCCl>[CH:41]([NH:44][C:26]1[N:25]=[C:24]([O:23][CH:21]2[CH2:22][CH:18]3[CH:19]([C:31](=[O:32])[N:33]([CH3:34])[CH2:35][CH2:36][CH2:37][CH2:38][CH:39]=[CH:13][CH:11]4[C:10]([C:8]([NH:7][S:4]([CH:1]5[CH2:3][CH2:2]5)(=[O:6])=[O:5])=[O:9])([NH:15][C:16]3=[O:17])[CH2:12]4)[CH2:20]2)[CH:29]=[CH:28][N:27]=1)([CH3:43])[CH3:42]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 6363IsopropylamineHCID 72253694N-(1-Cyclopropanesulfonylaminocarbonyl-2-vinyl-cyclopropyl)-2-(hex-5-enyl-methyl-amino-carbonyl)-4-(2-chloropyrimidin-4-yloxy)-cyclopentane-carboxamide

생성물 1

HCID 75277257N-cyclopropylsulfonyl-13-methyl-2,14-dioxo-17-[2-(propan-2-ylamino)pyrimidin-4-yl]oxy-3,13-diazatricyclo[13.3.0.04,6]octadec-7-ene-4-carboxamide

시약·촉매·용매 2

HCID 111,2-Dichloroethane용매
HCID 8028
Tetrahydrofuran
용매

반응 조건

온도
150 °C

실험 절차

Compound 10f (30 mg, 0.05 mmol) and isopropylamine (excess) in THF (10 ml) was heated in a microwave oven at 110° C. for 30 min and then left at ambient temperature for 16 hrs. The solvent was stripped of and the residue was redissolved in DCE (15 ml) and degassed with nitrogen. Hoyeda-Grubbs II catalyst (7 mg) was added and the mixture was heated in a microwave oven at 150° C. for 10 min. The mixture was concentrated to dryness and purified by prep. HPLC-MS-UV which gave the pure title compound (3.1 mg), (M+H)+=589.2.

후처리

  1. customdegassed with nitrogen
  2. additionHoyeda-Grubbs II catalyst (7 mg) was added
  3. concentrationThe mixture was concentrated to dryness
  4. custompurified by prep

출처 및 근거

ORD 기록
ord-4de7c34782bd476aa8aed69a69286c35
출처 데이터셋
uspto-grants-2015_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08937080B2

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