Citric Acid → HCID 178493585, 화합물
반응식
Cl[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[N:5]=[C:4]([O:10][CH3:11])[N:3]=1.C1N2CCN(CC2)C1.C(=O)([O-])[O-:21].[K+].[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>O>[CH3:11][O:10][C:4]1[N:3]=[C:2]([OH:21])[CH:7]=[C:6]([O:8][CH3:9])[N:5]=1참가 물질
6
실험 절차
A suspension of 4-chloro-2,6-dimethoxy-pyrimidine (4.9 g, 28 mmol), DABCO (6.4 g, 57 mmol) and potassium carbonate (13.8 g, 100 mmol) was refluxed in water (150 ml) for one hour. The mixture was cooled acidified with 5% citric acid and extracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH. The combined organic phases were dried and evaporated which gave the title compound (1.5 g, 34%), (M+H)+1 157.
후처리
- temperatureThe mixture was cooled
- extractionextracted three times with ethyl acetate and three times with DCM with about 105 THF and 10% MeOH
- customThe combined organic phases were dried
- customevaporated which
출처 및 근거
- ORD 기록
- ord-d6bed3b2bfe94e3ca2d89ac0f0149c68
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08937080B2
반응 노트
불러오는 중…