4-Bromophenylalanine → Methyl 2-amino-3-(4-bromophenyl)propanoate

HRID 1429360노트

반응식

HRID 1429360 반응식
[NH2:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].Cl.[CH3:15]O>>[NH2:1][CH:2]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([Br:13])=[CH:11][CH:12]=1)[C:3]([O:5][CH3:15])=[O:4]

참가 물질

3

반응물 2

HCID 856814-BromophenylalanineHCID 21893726Hydrochloride methanol

생성물 1

HCID 21921420Methyl 2-amino-3-(4-bromophenyl)propanoate수율 92%

실험 절차

A mixture of 2-amino-3-(4-bromophenyl)propanoic acid 3c (24.4 g, 100 mmol) in HCl/MeOH (300 mL) was stirred at reflux overnight. TLC analysis indicated the total consumption of compound 3c. The mixture was concentrated to give 3d as a pale yellow solid (24 g, 92% yield).

후처리

  1. temperatureat reflux overnight
  2. customthe total consumption of compound 3c
  3. concentrationThe mixture was concentrated

출처 및 근거

ORD 기록
ord-966329986bdc4a8d80e563a78e7347fe
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940722B2

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