Potassium Carbonate → 4(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine

HRID 1429366노트

반응식

HRID 1429366 반응식
FC(F)(F)C(O)=O.Br[CH2:9][C:10]1[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=1[CH2:12][O:13][CH2:14][CH:15]([NH2:24])[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([Br:23])=[CH:19][CH:18]=1.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[Br:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][CH:15]2[NH:24][CH2:9][C:10]3[CH:28]=[CH:27][CH:26]=[CH:25][C:11]=3[CH2:12][O:13][CH2:14]2)=[CH:18][CH:19]=1

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 673822521((2-(Bromomethyl)benzyl)oxy)-3-(4-bromophenyl)propan-2-amine trifluoroacetic acid salt

생성물 1

HCID 674173634(4-Bromobenzyl)-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine수율 86%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of compound 3k (1.6 g, 3.9 mmol) and K2CO3 (1.6 g, 12 mmol) in dry THF (30 mL) was stirred at rt overnight. LCMS indicated the total consumption of compound 3k. The reaction mixture was filtered and the filtrate was evaporated in vacuum to give 3l as a white solid (1.1 g, 86% yield).

후처리

  1. customthe total consumption of compound 3k
  2. filtrationThe reaction mixture was filtered
  3. customthe filtrate was evaporated in vacuum

출처 및 근거

ORD 기록
ord-171454f8bf764c998f04d306ce529fd9
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940722B2

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