Potassium Carbonate → (R)-4-Allyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
반응식
Br[CH2:2][C:3]1[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=1[CH2:5][O:6][CH2:7][C@H:8]([NH2:12])[CH2:9][CH:10]=[CH2:11].C([O-])([O-])=O.[K+].[K+]>CCO>[CH2:9]([C@H:8]1[NH:12][CH2:2][C:3]2[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=2[CH2:5][O:6][CH2:7]1)[CH:10]=[CH2:11]참가 물질
4
실험 절차
To a solution of compound 18k (2.0 g, 7.0 mmol) in EtOH (20 mL) was added K2CO3 (4.8 g, 35.0 mmol) portionwise. The mixture was heated to reflux for 2 h to complete the reaction. The reaction mixture was cooled down to rt and concentrated under reduced pressure to give compound 18l (1.2 g, 84% yield), which was used without purification. LCMS (m/z): 204.1 (MH+).
후처리
- temperatureThe mixture was heated
- temperatureto reflux for 2 h
- customthe reaction
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-f36a4fd96e3f441ba28d122276245a65
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940722B2
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