Ammonium Hydroxide → (S)-1-Amino-3-(3,4-dihydroisoquinolin-2(1H)-yl)propan-2-ol
반응식
[O:1]1[CH2:3][C@H:2]1[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1.[NH4+:15].[OH-]>CCO>[NH2:15][CH2:3][C@H:2]([OH:1])[CH2:4][N:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6]1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
To a solution of (R)-2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline (200 mg, 5.2 mmol) in EtOH (20 mL) was added NH4OH (600 mg, 35.2 mmol) at −78° C. The reaction mixture was then warmed and heated at 100° C. for 3 h in a seal tube. The reaction mixture was concentrated and the crude product was used in next step without further purification. LCMS (m/z): 207.1 (M+1).
후처리
- temperatureThe reaction mixture was then warmed
- concentrationThe reaction mixture was concentrated
- customthe crude product was used in next step without further purification
출처 및 근거
- ORD 기록
- ord-545d45be3fa0481c94ce734ab53b2fb4
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940726B2
반응 노트
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