Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Deschloroclofibrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Propanoic acid, 2-bromo-2-methyl-, ethyl ester | HCID 11745 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Deschloroclofibrate | HCID 86476 | 47.7% |
반응 단계
To a solution of phenol (2 g, 21.25 mmol) in CH3CN (50 mL) was added ethyl 2-bromo-2-methylpropanoate (5 g, 25.5 mmol) and Cs2CO3 (20 g, 63.75 mmol) at 25° C. The mixture was heated at reflux for 16 h then water (100 mL) added and extracted with ethyl acetate (2×50 mL). The organic layer was washed with brine (30 mL), dried over Na2SO4 and concentrated to give the title compound (2.1 g, 47.7%) as colorless oil which was used in next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08940726B2 |
| 출처 데이터셋 | uspto-grants-2015_01 |
| ORD ID | ord-282f71e9c33841f5a7cfa6acbbd485ac |
| 출처 메모 | uspto-grants-2015_01 |