Ammonium Hydroxide → 6-(Trifluoromethyl)pyridazin-3-amine
반응식
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:6][CH:7]=1.[OH-].[NH4+:13]>C1COCC1>[F:9][C:8]([F:11])([F:10])[C:5]1[N:4]=[N:3][C:2]([NH2:13])=[CH:7][CH:6]=1참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of 3-chloro-6-trifluoromethyl-pyridazine (1.6 g, 8.8 mmol) (prepared by a procedure similar to that described in Tetrahedron, 1999, 55 (52), 15067-15070) and ammonium hydroxide (30 ml) in THF (10 ml) was heated at 100° C. in a microwave reactor (Emrys Optimizer; 0-9 Barr) for 1 h. After this period, the reaction mixture was evaporated and the residue extracted with dichloromethane. The combined extracts were dried (MgSO4), filtered and the solvents evaporated in vacuo to give D6 (1.3 g, 93%). C5H4F3N3 requires 163; Found 164 (MH+)
후처리
- customprepared by a procedure similar to
- waitAfter this period
- customthe reaction mixture was evaporated
- extractionthe residue extracted with dichloromethane
- dry with materialThe combined extracts were dried (MgSO4)
- filtrationfiltered
- customthe solvents evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-7157ef4b97684c03a32b00946bae8736
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940743B2
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