Ethanol → 1262803-60-0

HRID 1429683노트

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HRID 1429683 반응식
Cl[C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][CH3:11])=[O:9])=[N:6][CH:7]=1.[C:12](=O)([O-])[O-].[K+].[K+].[CH3:18][CH2:19][OH:20]>>[CH2:19]([O:20][C:2]1[N:3]=[CH:4][C:5]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[N:6][CH:7]=1)[CH3:18]

참가 물질

4

반응물 3

HCID 702EthanolHCID 11430Potassium CarbonateHCID 406081Methyl 5-chloropyrazine-2-carboxylate

생성물 1

HCID 668696851262803-60-0수율 39%

실험 절차

To a slurry of methyl 5-chloropyrazine-2-carboxylate (250 mg, 1.45 mmol) in EtOH (5 mL) was added potassium carbonate (300 mg, 2.18 mmol). The resultant solution was stirred at RT for 2 hours. The mixture was concentrated. The residue was partitioned between water and CH2Cl2. The aqueous layer was extracted with CH2Cl2 (3×). The combined organic layers were dried over Na2SO4, filtered and concentrated to afford ethyl 5-ethoxypyrazine-2-carboxylate (110 mg, 39%) as a yellow solid.

후처리

  1. concentrationThe mixture was concentrated
  2. customThe residue was partitioned between water and CH2Cl2
  3. extractionThe aqueous layer was extracted with CH2Cl2 (3×)
  4. dry with materialThe combined organic layers were dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8c03065b53834a4092473177af7c6f8f
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940748B2

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