Triethylamine → 4-Bromo-1-methyl-2-phenoxybenzene
반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([OH:8])[CH:7]=1.[C:10]1(B(O)O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>ClCCl.C(OCC)(=O)C.CC([O-])=O.CC([O-])=O.[Cu+2]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:9])=[C:6]([O:8][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]=1참가 물질
7
실험 절차
A mixture of 5-bromo-2-methylphenol (1.0 g), phenylboronic acid (1.30 g), Cu(OAc)2 (0.97 g), and triethylamine (2.98 mL) in dichloromethane (50 mL) was stirred for 4 days. The mixture was diluted with ethyl acetate, washed four times with 1M aqueous NaOH solution and once with brine, dried over Na2SO4, filtered, and concentrated. The crude product was chromatographed on silica gel using 2% ethyl acetate in hexanes to afford the title compound.
후처리
- washwashed four times with 1M aqueous NaOH solution
- dry with materialonce with brine, dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- customThe crude product was chromatographed on silica gel using 2% ethyl acetate in hexanes
출처 및 근거
- ORD 기록
- ord-4f27d8df278e4efeab4bfa02028cf45f
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940737B2
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