Phenylboronic Acid → 2-Cyano-3-fluorobiphenyl

HRID 1430387노트

반응식

HRID 1430387 반응식
[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6](I)[C:3]=1[C:4]#[N:5].[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.C1(C)C=CC=CC=1.CCO.O>COCCOC.O>[F:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:3]=1[C:4]#[N:5]

참가 물질

5

반응물 3

HCID 66827Phenylboronic AcidHCID 5227222-Fluoro-6-iodobenzonitrileHCID 86587398Ethanol toluene water

생성물 1

HCID 235096522-Cyano-3-fluorobiphenyl

시약·촉매·용매 1

HCID 18180031Water 1,2-dimethoxyethane용매

실험 절차

The desired product was prepared by substituting 2-fluoro-6-iodobenzonitrile for Example 1A and phenylboronic acid for Example 1B in Example 1C. Additionally, toluene/EtOH/H2O (3:2:1) was substituted for DME/H2O as the solvent.

출처 및 근거

ORD 기록
ord-683e628802274827a95c8ef5670fba7a
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940778B2

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