Methylamine → 5-fluoro-N-methyl-2-nitroaniline

HRID 1430399노트

반응식

HRID 1430399 반응식
[CH3:1][NH2:2].F[C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[N+:11]([O-:13])=[O:12]>CO>[F:10][C:8]1[CH:7]=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([CH:9]=1)[NH:2][CH3:1]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 679672,4-Difluoronitrobenzene

생성물 1

HCID 229057745-fluoro-N-methyl-2-nitroaniline수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

An aqueous solution of 40% methyl amine (61 mL, 0.71 mol) was added dropwise to a methanol solution (200 mL) of 2,4-difluoronitrobenzene (46.7 g, 0.29 mol) under ice cooling, and the mixture was stirred for 1 hour under the same temperature. The reaction solution was poured into ice water. Precipitated crystals were collected by filtration, followed by washing with water. The resulting crystals were dried at 50° C., thereby obtaining 47.6 g of a yellow, powdery target compound (yield: 95%).

후처리

  1. customPrecipitated crystals
  2. filtrationwere collected by filtration
  3. washby washing with water
  4. customThe resulting crystals were dried at 50° C.

출처 및 근거

ORD 기록
ord-2bd870b8d0c641ecb21d08a7c687a969
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940889B2

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