10-Oxa-tricyclo[5.2.1.0*2,6*]dec-8-ene-3,5-dione → 10-Oxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione
반응식
[CH:1]12[O:10][CH:7]([CH:8]=[CH:9]1)[CH:6]1[CH:2]2[C:3](=[O:12])[CH2:4][C:5]1=[O:11]>CO.[Pd]>[CH:7]12[O:10][CH:1]([CH2:9][CH2:8]1)[CH:2]1[CH:6]2[C:5](=[O:11])[CH2:4][C:3]1=[O:12]참가 물질
4
실험 절차
(1RS,2SR,6RS,7SR)-10-oxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (2.1 g, 12.8 mmol), prepared in Example 1, Step 5, is dissolved in warm methanol (180 ml) and the mixture is allowed to cool to room temperature. The mixture is then hydrogenated in the presence of 5% palladium on carbon (approx. 50 mg) at 3.5 bar for 4 hours. The catalyst is removed by filtration through diatomaceous earth and the filtrate is concentrated under reduced pressure to afford (1RS,2SR,6RS,7SR)-10-oxatricyclo[5.2.1.02,6]decane-3,5-dione.
후처리
- customThe catalyst is removed by filtration through diatomaceous earth
- concentrationthe filtrate is concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-270b0e202ca2433f86f4bee9e8495a05
- 출처 데이터셋
- uspto-grants-2015_01
- 특허 번호
- US08940913B2
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