4-Morpholino-2-nitrobenzonitrile → 2-Amino-4-(4-morpholinyl)benzonitrile

HRID 1431246

반응식

HRID 1431246 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N+:15]([O-])=O)[CH:8]=2)[CH2:3][CH2:2]1>CO.[Pd]>[NH2:15][C:9]1[CH:8]=[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]

참가 물질

4

반응물 1

HCID 134992654-Morpholino-2-nitrobenzonitrile

생성물 1

HCID 134992832-Amino-4-(4-morpholinyl)benzonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 4-morpholino-2-nitrobenzonitrile (300 mg, 0.24 mmol) in MeOH (140 mL) was reduced using a continuos flow hydrogenation reactor (flow rate: 1 mL/min, 10% mol Pd/C, temperature 40° C., H2 pressure: 10 atm) to give 2-amino-4-morpholinobenzonitrile.

출처 및 근거

ORD 기록
ord-f8028d6e3d29430db727166dde4e97db
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940724B2

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