Acetic Acid → 2-Amino-4-(4-morpholinyl)benzonitrile

HRID 1431290노트

반응식

HRID 1431290 반응식
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[C:9]([N+:15]([O-])=O)[CH:8]=2)[CH2:3][CH2:2]1.C(O)(=O)C>[Zn]>[NH2:15][C:9]1[CH:8]=[C:7]([N:4]2[CH2:3][CH2:2][O:1][CH2:6][CH2:5]2)[CH:14]=[CH:13][C:10]=1[C:11]#[N:12]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 134992654-Morpholino-2-nitrobenzonitrile

생성물 1

HCID 134992832-Amino-4-(4-morpholinyl)benzonitrile

시약·촉매·용매 1

HCID 23994Zinc촉매

실험 절차

To a mixture of 4-morpholino-2-nitrobenzonitrile (388 mg, 1664 μmol) in acetic acid (6.00 mL, 104809 μmol) at rt was added all at once zinc powder (1632 mg, 24955 μmol). An exotherm developed. The reaction was stirred at ambient temperature for 2 h then filtered, and rinsed with EtOAc. The filtrate was concd under reduced pressure to afford a slightly yellow solid. Mass Spectrum (ESI) m/e=204.1 (M+1).

후처리

  1. filtrationthen filtered
  2. washrinsed with EtOAc
  3. customto afford a slightly yellow solid

출처 및 근거

ORD 기록
ord-6f4a4057ac604783850ee04112a798f7
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940724B2

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