2-Piperidone → 1-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one

HRID 1431317노트

반응식

HRID 1431317 반응식
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][C:17]1=[O:22]>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][C:17]2=[O:22])[C:11]=1[CH3:12]

참가 물질

3

반응물 2

HCID 126652-PiperidoneHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

생성물 1

HCID 596315521-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one

실험 절차

Prepared according to Procedure I using 2,4-dichloro-5,7-difluoro-3-methylquinoline (250 mg, 1.01 mmol) and piperidin-2-one to give 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperidin-2-one. Mass Spectrum (ESI) m/e=311.0 (M+1).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-a3fdce276f8542a19885881444239e6c
출처 데이터셋
uspto-grants-2015_01
특허 번호
US08940724B2

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