Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(2-Oxopropyl)amine → 1-Trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (2-Oxopropyl)amine | HCID 215 | — |
| 반응물 | N-Trifluoroacetylprolyl chloride | HCID 3082449 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide | HCID 86587583 | — |
반응 단계
A solution of (S)-N-(trifluoroacetyl)prolyl chloride (Aldrich) 1 equiv. in DCM is treated with 1-amino-propan-2-one (1.5 equiv.) in pyridine at rt for 5 hours. After usual work up, it provides 1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07612059B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-b374ca01871c4aa49186c5c35b11b1bf |
| 출처 메모 | uspto-grants-2009_11 |