(S)-6-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-ol → (S)-5-hydroxy-5,6,7,8-tetrahydronapthalene-2-carbaldehyde

HRID 1431988노트

반응식

HRID 1431988 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C@@H:9]([OH:13])[CH2:8][CH2:7][CH2:6]2>C(Cl)Cl.CC#N.O=[Mn]=O>[OH:13][C@H:9]1[CH2:8][CH2:7][CH2:6][C:5]2[CH:4]=[C:3]([CH:2]=[O:1])[CH:12]=[CH:11][C:10]1=2

참가 물질

4

반응물 1

HCID 59771808(S)-6-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-ol

생성물 1

HCID 59771799(S)-5-hydroxy-5,6,7,8-tetrahydronapthalene-2-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 21877088Acetonitrile methylene chloride용매

실험 절차

To a stirred solution of (S)-6-(hydroxymethyl)-1,2,3,4-tetrahydronaphthalen-1-ol (2.5 g, 14 mmol) in CH2Cl2/MeCN (1:1, 80 mL) was added MnO2 (6.1 g, 70. mmol). The reaction mixture was stirred for 16 h at RT. The solid was filtered off, and the filtrate was concentrated to afford the title compound. MS (m/z): 277.2 (M+H).

후처리

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-2ab2e40de1684374867fadc6612a25fb
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612060B2

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