Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium sulfate decahydrate → N-(4-(aminomethyl)-2,6-dichlorophenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium sulfate decahydrate | HCID 62649 | — |
| 반응물 | N-(2,6-dichloro-4-cyanophenyl)acetamide | HCID 2735977 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-(4-(aminomethyl)-2,6-dichlorophenyl)acetamide | HCID 58962993 | 30% |
반응 단계
Step AT2. To a solution of 4-acetamido-3,5-dichloro-benzonitrile (114 mg, 0.5 mmol) in 5 mL of THF was added lithium aluminum hydride (120 mg, 3.2 mmol) in portion and the resulting mixture was stirred for 3 hours. Sodium sulfate decahydrate (1 g, 3.2 mmol) was added in portion and the mixture was stirred for 30 minutes. The solid was filtered off and the filtration was concentrated. Residue was purified by HPLC to give 4-acetamido-3,5-dichloro-benzylamine (35 mg, 30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07612069B2 |
| 출처 데이터셋 | uspto-grants-2009_11 |
| ORD ID | ord-27e4930584df49deaf113f207d70c4b4 |
| 출처 메모 | uspto-grants-2009_11 |