1-Isopropylpiperazine → N-[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-acetamide

HRID 1432146

반응식

HRID 1432146 반응식
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1.[CH3:12][CH:13]([N:15]1[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]1)[CH3:14]>CN(C=O)C>[CH:13]([N:15]1[CH2:20][CH2:19][N:18]([C:2]2[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=2)[CH2:17][CH2:16]1)([CH3:14])[CH3:12]

참가 물질

4

반응물 2

HCID 780131-IsopropylpiperazineHCID 2049955N-(2-chloropyridin-4-yl)acetamide

생성물 1

HCID 68946851N-[2-(4-Isopropyl-piperazin-1-yl)-pyridin-4-yl]-acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
150 °C

실험 절차

A mixture of 4.6 g (27 mmol) N-(2-chloropyridin-4-yl)acetamide (commercially available) and 5.2 g (41 mmol) 1-(2-propyl-)-piperazine in 2 ml DMF was heated to 150° C. for 4 h. Purification of the crude mixture with flash column chromatography on silica eluting with a gradient formed from DCM (1% NEt3) and methanol yielded after evaporation of the product fractions 3.38 g (47%) of the title compound as white solid. MS: (m/e): 263.4 (MH+).

후처리

  1. customPurification of the crude mixture with flash column chromatography on silica eluting with a gradient
  2. customformed from DCM (1% NEt3) and methanol
  3. customyielded
  4. customafter evaporation of the product fractions 3.38 g (47%) of the title compound as white solid

출처 및 근거

ORD 기록
ord-ff9d444a46944987a2d5284df9cc8c52
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612076B2

연결된 노트

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