Water → 2-(2-tetrahydrofuranyl)-5-methanesulfonyl-1H-indole

HRID 1432234노트

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HRID 1432234 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]1[N:7](S(C2C=CC=CC=2)(=O)=O)[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2.[OH-].[K+].O>O1CCCC1.CO>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2

참가 물질

5

반응물 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 225044492-(2-Tetrahydrofuranyl)-5-methanesulfonyl-1-benzenesulfonylindole

생성물 1

HCID 225044162-(2-tetrahydrofuranyl)-5-methanesulfonyl-1H-indole수율 82.2%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

To a solution of the compound obtained in Example 13 (1) (210 mg) in a mixture of tetrahydrofuran/methanol (2:1, 15 ml), a 1N aqueous potassium hydroxide solution (1.6 ml) was added and the mixture was stirred at 100° C. for 2 hours. The reaction solution was then poured into water, extracted with dichloromethane, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting residue was separated using silica gel preparative thin-layer chromatography (hexane ethyl acetate=1:1) to obtain 113 mg of the desired product as a white powder.

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was separated

출처 및 근거

ORD 기록
ord-da412c11b5ed440ea554ecfc5b6c0eb7
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612070B2

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