참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,4-Dioxane | HCID 31275 | — |
| 반응물 | Potassium Acetate | HCID 517044 | — |
| 반응물 | 3-(Trimethylsilylethynyl)pyridine | HCID 4100857 | — |
| 반응물 | 1-Benzenesulfonylamino-2-iodo-4-methanesulfonylbenzene | HCID 22504376 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Benzenesulfonyl-5-methanesulfonyl-2-(3-pyridyl)indole | HCID 22504414 | 63% |
반응 단계
A mixture of 3-trimethylsilylethynylpyridine (1.07 g), 2-benzenesulfonylamino-3-iodo-5-methanesulfonylbenzene (1.75 g), potassium acetate (1.60 g), cuprous iodide (60 mg), dichlorobis(triphenylphosphine)palladium (0.20 g) and 1,4-dioxane (4 ml) was stirred at 100° C. for 12 hours under nitrogen atmosphere. To the reaction solution were added water and ethyl acetate. The insolubles were filtered off. The filtrate was extracted with ethyl acetate, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The resulting residue was subjected to silica gel column chromatography (hexane:ethyl acetate=1:3) to obtain 1.04 g of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07612070B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_11 |
|---|
| ORD ID | ord-6e4de20a21ef493895c8a9c5532b031c |
|---|
| 출처 메모 | uspto-grants-2009_11 |
|---|
