p-Toluenesulfonic acid → HCID 9952234, 화합물

HRID 1432286노트

반응식

HRID 1432286 반응식
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][N:7]2[C:11]3=[N:12][CH:13]=[C:14]([S:16]([CH3:19])(=[O:18])=[O:17])[N:15]=[C:10]3[CH:9]=[C:8]2[C:20](=[S:22])[NH2:21])=[CH:4][CH:3]=1.CO[CH:27](OC)[CH2:28]Br.C1(C)C=CC(S(O)(=O)=O)=CC=1>C(O)(=O)C>[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][N:7]2[C:11]3=[N:12][CH:13]=[C:14]([S:16]([CH3:19])(=[O:17])=[O:18])[N:15]=[C:10]3[CH:9]=[C:8]2[C:20]2[S:22][CH:27]=[CH:28][N:21]=2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 816722-Bromo-1,1-dimethoxyethaneHCID 22504367HCID 22504367, 화합물

생성물 1

HCID 9952234HCID 9952234, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 5-(4-fluorobenzyl)-2-methanesulfonyl-5H-pyrrolo[2,3-b]pyrazine-6-thioamide (90 mg), bromoacetaldehyde dimethylacetal (0.06 ml), p-toluenesulfonic acid (4 mg) and acetic acid (1 ml) was stirred at 100° C. for 1.5 hours. The reaction solution was separated using silica gel column chromatography (hexane:ethyl acetate=0.2:1).to obtain the desired product (30 mg).

후처리

  1. customThe reaction solution was separated

출처 및 근거

ORD 기록
ord-4b4d3ff35cca4d07bcf854e5603e3a6c
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612070B2

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