홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,2-Dichloroethane → N-[4-(dimethylaminoimino)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

HRID 1432553
노트
인쇄 미리보기

반응식

HRID 1432553 반응식
ClC1C=CC(NC([C:11]2[S:19][C:18]3[CH2:17][CH:16]([C:20]([OH:22])=O)[NH:15][CH2:14][C:13]=3[CH:12]=2)=O)=CC=1.[CH3:23][N:24]([N:26]=[C:27]1[CH:32]=[CH:31][C:30]([NH2:33])=[CH:29][CH2:28]1)[CH3:25].[CH2:34]([Cl:37])[CH2:35]Cl.[OH2:38]>CN(C=O)C>[CH3:25][N:24]([N:26]=[C:27]1[CH:28]=[CH:29][C:30]([NH:33][C:20]([CH:16]2[N:15]([C:14]([NH:15][C:16]3[CH:20]=[CH:35][C:34]([Cl:37])=[CH:18][CH:17]=3)=[O:38])[CH2:14][C:13]3[CH:12]=[CH:11][S:19][C:18]=3[CH2:17]2)=[O:22])=[CH:31][CH2:32]1)[CH3:23]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 111,2-DichloroethaneHCID 962WaterHCID 686968834-(Dimethylaminoimino)phenylamineHCID 131727718(4-Chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid

생성물 1

HCID 86606524N-[4-(dimethylaminoimino)phenyl]-5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5N-(4-chlorophenylaminocarbonyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine-6-carboxylic acid (42 mg, 0.12 mmol) and 4-(dimethylaminoimino)phenylamine (42 mg, 0.26 mmol) in DMF (3 mL) and H2O (0.5 mL) at room temperature, EDC (72 mg, 0.38 mmol) was added. The mixture was stirred at room temperature overnight. It was concentrated in vacuo. The residue was purified by HPLC to give the titled compound as a powder (26 mg). MS 482.3 and 484.4 (M+H, Cl pattern).

후처리

  1. concentrationIt was concentrated in vacuo
  2. customThe residue was purified by HPLC

출처 및 근거

ORD 기록
ord-7e53d070e0c447f498207f7edd452464
출처 데이터셋
uspto-grants-2009_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07612089B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트