Tetrahydrofuran → 3-[3-chloro-5-(2-methyl-2H-pyrazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

반응식

[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[N:3]1.C1COCC1.[Li]CCCC.Br[C:18]1[S:22][C:21]([C:23]2[N:27]3[N:28]=[C:29]([CH3:37])[CH:30]=[C:31]([CH:32]([CH2:35][CH3:36])[CH2:33][CH3:34])[C:26]3=[N:25][C:24]=2[CH3:38])=[C:20]([Cl:39])[CH:19]=1>CCOC(C)=O.[Cl-].[Cl-].[Zn+2].C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[Cl:39][C:20]1[CH:19]=[C:18]([C:6]2[N:2]([CH3:1])[N:3]=[CH:4][CH:5]=2)[S:22][C:21]=1[C:23]1[N:27]2[N:28]=[C:29]([CH3:37])[CH:30]=[C:31]([CH:32]([CH2:33][CH3:34])[CH2:35][CH3:36])[C:26]2=[N:25][C:24]=1[CH3:38]