HCID 17985179, 화합물 → HCID 67108942, 화합물

HRID 1432946

반응식

HRID 1432946 반응식
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH2:15][C:14]3=[O:19])[CH:8]=2)[N:3]=1.[Cl:20][C:21]1[S:25][C:24]([C:26]2[S:27][C:28]([S:31](Cl)(=[O:33])=[O:32])=[CH:29][CH:30]=2)=[CH:23][CH:22]=1>>[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([S:31]([C:28]4[S:27][C:26]([C:24]5[S:25][C:21]([Cl:20])=[CH:22][CH:23]=5)=[CH:30][CH:29]=4)(=[O:32])=[O:33])[CH2:15][C:14]3=[O:19])[CH:8]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 17985179HCID 17985179, 화합물HCID 220172805'-Chloro-2,2'-bithiophene-5-sulfonyl chloride

생성물 1

HCID 67108942HCID 67108942, 화합물

실험 절차

The title compound is prepared as described in Example 101 using 1-(2-aminoquinolin-6-ylmethyl)piperazin-2-one, EXAMPLE 67, and 5′-chloro-[2,2′]bithiophenyl-5-sulfonyl chloride, EXAMPLE 2. The crude product is triturated in CH2Cl2 and filtered to provide the title compound as a white solid. 1H NMR (d6-DMSO, 300 MHz) δ7.82 (d, 1H), 7.68 (d, 1H), 7.42 (m, 3H), 7.36 (d, 1H), 7.25 (d, 1H), 7.20 (d, 1H), 6.70 (d, 1H), 6.43 (bs, 2H), 4.53 (s, 2H), 3.78 (s, 2H), 3.31 (m, 4H). MS (ion spray) m/z 519, 521, (M+H), Cl pattern.

후처리

  1. customThe title compound is prepared
  2. customThe crude product is triturated in CH2Cl2
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-fc30cf20f9fd46eabde1851ccceb4328
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612075B2

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