1-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-one → HCID 54022526, 화합물

HRID 1432977노트

반응식

HRID 1432977 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][NH:16][CH:15]([CH2:19][O:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.Br[CH2:24]/[CH:25]=[CH:26]/[C:27]1[S:28][C:29]([Cl:32])=[CH:30][CH:31]=1>>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([CH2:12][N:13]3[CH2:18][CH2:17][N:16]([CH2:24][CH:25]=[CH:26][C:27]4[S:28][C:29]([Cl:32])=[CH:30][CH:31]=4)[C@@H:15]([CH2:19][O:20][CH3:21])[C:14]3=[O:22])=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 179852231-(4-Amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-oneHCID 217085162-(3-Bromo-(E)-propenyl)-5-chloro-thiophene

생성물 1

HCID 54022526HCID 54022526, 화합물

실험 절차

The title compound is prepared as described in EXAMPLE 278 using 1-(4-amino-quinazoline-7-ylmethyl)-3-methoxymethyl-piperazine-2-one, EXAMPLE 75 and 2-(3-bromo-(E)-propenyl)-5-chloro-thiophene EXAMPLE 17. 1H NMR (d6-DMSO, 300 MHz) δ9.74 (bs, 2H), 8.80 (s, 1H), 8.38 (d, 1H), 7.69 (m, 2H), 7.02 (dd, 1H), 6.84 (d, 1H), 6.02 (m, 1H), 4.76 (AB, 2H), 3.86 (m, 4H), 3.30 (s, 3H), 3.23 (m, 2H), 3.02 (m, 2H). MS (ion spray), m/z, 458, 460, (M+H) (Cl pattern). Elemental analysis, cal C22H24ClN5O2S.2C2HF3O2.1.45H2O % C=43.85, % H=4.09, % N=9.83; found % C=43.92, % H=3.61, % N=9.63.

출처 및 근거

ORD 기록
ord-46b5df038a44420bb63d32360f1f50b1
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612075B2

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