Acetic Acid → Temozolomide

HRID 1433126

반응식

HRID 1433126 반응식
[CH3:1][N:2]1[N:11]=[N:10][C:9]2[N:5]([CH:6]=[N:7][C:8]=2[C:12]([NH2:14])=[O:13])[C:3]1=[O:4].Cl.C(O)(=O)C.C(#N)C>O>[CH3:1][N:2]1[N:11]=[N:10][C:9]2[N:5]([CH:6]=[N:7][C:8]=2[C:12]([NH2:14])=[O:13])[C:3]1=[O:4]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 6342AcetonitrileHCID 11658676HCID 11658676, 화합물

생성물 1

HCID 5394Temozolomide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

According to the present invention, the dissolution of Temozolomide hydrochloride in the mixture of acetic acid, acetonitrile, and water is complete (at pH range of 3-4), results in the precipitation of Temozolomide upon cooling.

출처 및 근거

ORD 기록
ord-73fd4603a2d447539955f29b9ce3c3ea
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07612202B2

연결된 노트

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