Sodium Bicarbonate → Ethyl piperazine-1-acetate
반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.C(=O)(O)[O-].[Na+]>FC(F)(F)C(O)=O>[CH2:18]([O:17][C:15](=[O:16])[CH2:14][N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)[CH3:19]참가 물질
4
실험 절차
A solution of 4-ethoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester in 90% trifluroacetic acid (5 ml) was stirred for 3 h. The mixture was basified with saturated sodium bicarbonate solution and concentrated. The residue was triturated with ethylacetate (30 ml) and filtered. The filtrate was concentrated to leave piperazin-1-yl-acetic acid ethyl ester as a yellow oil (ca 1.5 g)
후처리
- concentrationconcentrated
- customThe residue was triturated with ethylacetate (30 ml)
- filtrationfiltered
- concentrationThe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-af938514c5d94ba69279ae45187d08c5
- 출처 데이터셋
- uspto-grants-2009_11
- 특허 번호
- US07612201B2
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